Goserelin acetate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

醋酸戈舍瑞林是一种合成的促性腺激素释放激素长效激动剂，用于治疗癌症。

Goserelin acetate is a synthetic long-acting agonist of gonadotropin-releasing hormone, used in treatments of cancer.(In Vitro):Goserelin (1 nM-1 mM; 48-72 hours) promotes EOC cell apoptosis.Goserelin (100 μM; 24-72 hours) regulates the expression of human apoptosis-related genes in SKOV3-ip cells.Goserelin (100 μM; 24-72 hours) promotes EOC cell apoptosis by upregulating FOXO1 through the PI3K/AKT signaling pathway.(In Vivo):Goserelin (100 μg; s.c.; daily; for 19 days) significantly increases the proportion of apoptotic cells in the subcutaneous xenograft tumors.

Apoptosis Analysis Cell Line:SKOV3 cells, SKOV3-ip cells, A2780 cells (human EOC cell lines)Concentration:1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 100 μM, 1 mM Incubation Time:48 hours, 72 hours Result:Significantly increased the total apoptosis rate of SKOV3-ip, SKOV3 and A2780 cells.Western Blot Analysis Cell Line:SKOV3 cells, SKOV3-ip cells, A2780 cells (human EOC cell lines)Concentration:1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 100 μM, 1 mM Incubation Time:48 hours, 72 hours Result:The expression of cleaved-caspase-3 and cleaved-PARP were observably increased at 100 μM.RT-PCR Cell Line:SKOV3-ip cells Concentration:100 μM Incubation Time:24 hours, 48 hours, 72 hours Result:Expression of human apoptosis-related genes regulated

Animal Model:Five-week-old specific-pathogen free (SPF) female nude mice (18-20 g), subcutaneous xenograft tumor model Dosage:100 μg/mice Administration:Subcutaneous injection, daily, for 19 days Result:Significantly increased the proportion of apoptotic cells in the subcutaneous xenograft tumors

ICI-118630 acetate

Others

Other Targets

GNRHR

Endocrinology

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145781-92-6

1329.46

C61H88N18O16

>98% (HPLC)

DMSO : ≥ 28 mg/mL; 21.06 mM

CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NNC(=O)N)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](Cc1ccc(cc1)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1.CC(=O)O

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(-20℃)

With Ice Pack

≥ 2 years